Dichloromethane → HCID 20553737, compound

HRID 1814766Notes

Reaction equation

HRID 1814766 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=O)C(C(O)=O)[CH:2]=1.[C:15](Cl)(=O)[C:16]([Cl:18])=[O:17].[Cl:21]CCl>CN(C=O)C>[Cl:21][C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:1]=[CH:2][C:15]=1[C:16]([Cl:18])=[O:17]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 24869614HCID 24869614, compound

Product 1

HCID 20553737HCID 20553737, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Procedure

A suspension of 4-quinolone-3-carboxylic acid (189 mg) in dichloromethane (5 ml) was treated with 1 drop DMF and oxalyl chloride (0.2 ml), stirred 1.5 hours and the solvent evaporated. The residue was briefly put under vacuum to provide 4-chloroquinoline-3-carbonyl chloride as a white solid.

Workup

  1. customthe solvent evaporated

Sources & evidence

ORD record
ord-30566e4eea564ee8bbd3b38fd719a3c9
Source dataset
uspto-grants-2005_04
Patent number
US06878704B2

Reaction notes

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