Pyridine → HCID 135604937, compound

HRID 1814842Notes

Reaction equation

HRID 1814842 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:24][CH2:25][CH2:26][CH3:27])=[C:6]([C:8]2[NH:13][C:12](=[O:14])[C:11]3=[C:15]([CH3:23])[N:16]=[C:17]([CH:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[N:10]3[N:9]=2)[CH:7]=1.[Cl:28][C:29]1[S:30][C:31]([Cl:38])=[CH:32][C:33]=1[S:34](Cl)(=[O:36])=[O:35].N1C=CC=CC=1>O1CCCC1>[Cl:28][C:29]1[S:30][C:31]([Cl:38])=[CH:32][C:33]=1[S:34]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([O:24][CH2:25][CH2:26][CH3:27])=[C:6]([C:8]2[NH:13][C:12](=[O:14])[C:11]3=[C:15]([CH3:23])[N:16]=[C:17]([CH:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[N:10]3[N:9]=2)[CH:7]=1)(=[O:36])=[O:35]

Participants

5

Reactant 3

HCID 1049PyridineHCID 27360942,5-Dichlorothiophene-3-sulfonyl chlorideHCID 1356049252-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

Product 1

HCID 135604937HCID 135604937, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

150 mg (0.408 mmol) of the compound from example 44A are reacted with 308 mg (1.224 mmol) of 2,5-dichlorothiophene-3-sulfonyl chloride and 0.33 ml (4.08 mmol) of pyridine in tetrahydrofuran for 4 hours.

Sources & evidence

ORD record
ord-d4fdb73c34e24e6ea726d5ad6b79e1bf
Source dataset
uspto-grants-2005_04
Patent number
US06878708B2

Reaction notes

Loading…