HRID1814845

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

HCID516892

Sodium Bicarbonate

CHNaO3

结构：CCOc1ccc(NC(=O)C2CN(C(=O)OC(C)(C)C)CCN2C(=O)OC(C)(C)C)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1

HCID135698333

未命名化合物

PRODUCTS

生成物

结构：CCOc1ccc(NC(=O)C2CNCCN2)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1

HCID135604946

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

132 mg (0.198 mmol) of the compound from example 48 are treated with 5 ml of trifluoroacetic acid for 90 minutes the solution is then concentrated dichloromethane and 10% strength NaHCO3 solution are added to the residue and the organic phase is dried and concentrated under reduced pressure.

WORKUP

后处理

customthe organic phase is dried
concentrationconcentrated under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a4a9d23d6648456ea2e2e9e24682aba6
来源数据集: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06878708B2
来源说明: uspto-grants-2005_04

反应 SMILES

C(OC([N:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH:9]1[C:21]([NH:23][C:24]1[CH:25]=[CH:26][C:27]([O:46][CH2:47][CH3:48])=[C:28]([C:30]2[NH:35][C:34](=[O:36])[C:33]3=[C:37]([CH3:45])[N:38]=[C:39]([CH:40]4[CH2:44][CH2:43][CH2:42][CH2:41]4)[N:32]3[N:31]=2)[CH:29]=1)=[O:22])=O)(C)(C)C.FC(F)(F)C(O)=O.C([O-])(O)=O.[Na+]>ClCCl>[CH2:47]([O:46][C:27]1[CH:26]=[CH:25][C:24]([NH:23][C:21]([CH:9]2[CH2:10][NH:11][CH2:12][CH2:13][NH:8]2)=[O:22])=[CH:29][C:28]=1[C:30]1[NH:35][C:34](=[O:36])[C:33]2=[C:37]([CH3:45])[N:38]=[C:39]([CH:40]3[CH2:44][CH2:43][CH2:42][CH2:41]3)[N:32]2[N:31]=1)[CH3:48]