Trifluoroacetic acid → HCID 135604946, compound

HRID 1814845Notes

Reaction equation

HRID 1814845 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH:9]1[C:21]([NH:23][C:24]1[CH:25]=[CH:26][C:27]([O:46][CH2:47][CH3:48])=[C:28]([C:30]2[NH:35][C:34](=[O:36])[C:33]3=[C:37]([CH3:45])[N:38]=[C:39]([CH:40]4[CH2:44][CH2:43][CH2:42][CH2:41]4)[N:32]3[N:31]=2)[CH:29]=1)=[O:22])=O)(C)(C)C.FC(F)(F)C(O)=O.C([O-])(O)=O.[Na+]>ClCCl>[CH2:47]([O:46][C:27]1[CH:26]=[CH:25][C:24]([NH:23][C:21]([CH:9]2[CH2:10][NH:11][CH2:12][CH2:13][NH:8]2)=[O:22])=[CH:29][C:28]=1[C:30]1[NH:35][C:34](=[O:36])[C:33]2=[C:37]([CH3:45])[N:38]=[C:39]([CH:40]3[CH2:44][CH2:43][CH2:42][CH2:41]3)[N:32]2[N:31]=1)[CH3:48]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 135698333HCID 135698333, compound

Product 1

HCID 135604946HCID 135604946, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

132 mg (0.198 mmol) of the compound from example 48 are treated with 5 ml of trifluoroacetic acid for 90 minutes the solution is then concentrated dichloromethane and 10% strength NaHCO3 solution are added to the residue and the organic phase is dried and concentrated under reduced pressure.

Workup

  1. customthe organic phase is dried
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-a4a9d23d6648456ea2e2e9e24682aba6
Source dataset
uspto-grants-2005_04
Patent number
US06878708B2

Reaction notes

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