1-Isocyanato-4-[(trifluoromethyl)sulfanyl]benzene → HCID 135604947, compound

HRID 1814846Notes

Reaction equation

HRID 1814846 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:24][CH2:25][CH3:26])=[C:6]([C:8]2[NH:13][C:12](=[O:14])[C:11]3=[C:15]([CH3:23])[N:16]=[C:17]([CH:18]([CH2:21][CH3:22])[CH2:19][CH3:20])[N:10]3[N:9]=2)[CH:7]=1.[F:27][C:28]([F:40])([F:39])[S:29][C:30]1[CH:35]=[CH:34][C:33]([N:36]=[C:37]=[O:38])=[CH:32][CH:31]=1>O1CCCC1>[CH2:19]([CH:18]([C:17]1[N:10]2[C:11]([C:12](=[O:14])[NH:13][C:8]([C:6]3[CH:7]=[C:2]([NH:1][C:37]([NH:36][C:33]4[CH:34]=[CH:35][C:30]([S:29][C:28]([F:39])([F:27])[F:40])=[CH:31][CH:32]=4)=[O:38])[CH:3]=[CH:4][C:5]=3[O:24][CH2:25][CH3:26])=[N:9]2)=[C:15]([CH3:23])[N:16]=1)[CH2:21][CH3:22])[CH3:20]

Participants

4

Reactant 2

HCID 27333921-Isocyanato-4-[(trifluoromethyl)sulfanyl]benzeneHCID 135843655HCID 135843655, compound

Product 1

HCID 135604947HCID 135604947, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Analogously to the procedure of example 54, 230 mg (0.647 mmol) of the amino compound from example 48A are reacted with 284 mg (1.29 mmol) of 4-(trifluoromethylthio)phenyl isocyanate in 20 ml of tetrahydrofuran for 4 hours. The crude product is purified by silica gel chromatography using toluene and ethyl acetate as mobile phase.

Workup

  1. customThe crude product is purified by silica gel chromatography

Sources & evidence

ORD record
ord-a64469d75bc944e4b9d34ee46fa5ace9
Source dataset
uspto-grants-2005_04
Patent number
US06878708B2

Reaction notes

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