Methylamine → 6-AMINO-1-BENZYL-5-METHYLAMINOURACIL

HRID 1814950Notes

Reaction equation

HRID 1814950 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6](=[O:15])[NH:5][C:4](=[O:16])[C:3]=1Br.[CH3:18][NH2:19]>>[NH2:1][C:2]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6](=[O:15])[NH:5][C:4](=[O:16])[C:3]=1[NH:19][CH3:18]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 8221496-AMINO-1-BENZYL-5-BROMOURACIL

Product 1

HCID 7262256-AMINO-1-BENZYL-5-METHYLAMINOURACIL

Conditions

Temperature
5 °C

Procedure

6-Amino-1-benzyl-5-bromouracil (134 g) was stirred with 40% aqueous methylamine solution (750 ml) for 24 hours. After cooling to 5° C., the precipitate was filtered and dried under suction to provide 6-amino-1-benzyl-5-methylaminouracil (55 g).

Workup

  1. filtrationthe precipitate was filtered
  2. customdried under suction

Sources & evidence

ORD record
ord-03cb572469a64cfe963762ddab5d3eb1
Source dataset
uspto-grants-2005_04
Patent number
US06878715B1

Reaction notes

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