Hydrochloric Acid → HCID 54015081, compound

HRID 1814962Notes

Reaction equation

HRID 1814962 reaction equation
C([O:4][C@@H:5]([CH3:31])[CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[C:19](=[O:20])[C:18]2[N:17]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:16]([CH2:28][Cl:29])=[N:15][C:14]=2[N:13]([CH3:30])[C:11]1=[O:12])(=O)C.Cl>CCOCC>[OH:4][C@@H:5]([CH3:31])[CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[C:19](=[O:20])[C:18]2[N:17]([CH2:21][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[C:16]([CH2:28][Cl:29])=[N:15][C:14]=2[N:13]([CH3:30])[C:11]1=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53650909HCID 53650909, compound

Product 1

HCID 54015081HCID 54015081, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of (S)-1-(5-acetoxyhexyl)-7-benzyl-8-chloromethyl-3-methylxanthine (8.7 g, 19.5 mmol) was added a solution of hydrogen chloride in ether (1.0 M, 20 ml). After stirring at room temperature for 24 hours, the solvent was evaporated under reduced pressure to give (S)-1-(5-hydroxyhexyl)-7-benzyl-8-chloromethyl-3-methylxanthine (7.0 g, 89% yield) as a white solid.

Workup

  1. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-3fafdcffbbdc46f2a7f833e85178cc4e
Source dataset
uspto-grants-2005_04
Patent number
US06878715B1

Reaction notes

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