Hydrochloric Acid → HCID 54538731, compound

HRID 1814982Notes

Reaction equation

HRID 1814982 reaction equation
[OH:1][C@H:2]([CH3:24])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[C:16](=[O:17])[C:15]2[N:14](COCC)[C:13]([NH2:22])=[N:12][C:11]=2[N:10]([CH3:23])[C:8]1=[O:9].Cl>C(O)C>[OH:1][C@H:2]([CH3:24])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[C:16](=[O:17])[C:15]2[NH:14][C:13]([NH2:22])=[N:12][C:11]=2[N:10]([CH3:23])[C:8]1=[O:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54165680HCID 54165680, compound

Product 1

HCID 54538731HCID 54538731, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

(R)-1-(5-Hydroxyhexyl)-7-ethoxymethyl-8-amino-3-methylxanthine libraries synthesized as described in Example 33 were treated with a solution composed of concentrated hydrochloric acid and ethanol (1:4, 0.8 ml per well) and the block was heated in an oven at 80° C. for 12 hours. Remaining reagents and byproducts were evaporated under reduced pressure providing (R)-1-(5-hydroxyhexyl)-8-amino-3-methylxanthine libraries.

Workup

  1. additionwere treated with a solution
  2. customRemaining reagents and byproducts were evaporated under reduced pressure

Sources & evidence

ORD record
ord-1bd7f263aaa84a1db11be54d63a27c8c
Source dataset
uspto-grants-2005_04
Patent number
US06878715B1

Reaction notes

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