Formaldehyde → HCID 9818794, compound

HRID 1814996Notes

Reaction equation

HRID 1814996 reaction equation
Br.[NH2:2][CH:3]([CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)=[CH:14][CH:13]=1)[C:4](O)=O.[CH2:25]=[O:26].C(NCC)C.[OH-:32].[Na+]>C(OCC)(=O)C>[NH2:2][CH:3]([CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:14][CH:13]=1)[CH2:4][C:25]([OH:32])=[O:26]

Participants

6

Reactant 4

HCID 712FormaldehydeHCID 8021DiethylamineHCID 14798Sodium HydroxideHCID 9865699HCID 9865699, compound

Product 1

HCID 9818794HCID 9818794, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The acrylic acids 17 are prepared via the diacids 16 obtained by saponification in 6N sodium hydroxide under reflux, and then a Mannich reaction in the presence of paraformaldehyde, diethylamine in ethyl acetate under reflux.

Workup

  1. temperatureunder reflux
  2. temperatureunder reflux

Sources & evidence

ORD record
ord-8717c5f32604401586b5a5fbda19a057
Source dataset
uspto-grants-2005_04
Patent number
US06878723B1

Reaction notes

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