反应详情

Benzyl bromide (1.28 mL) is added to a suspension of potassium carbonate (2.98 g) in a solution of 8-hydroxy-3-methyl-1H-quinolin-2-one (1.26 g) in acetone (36 mL) at room temperature. The reaction mixture is refluxed for 18 hours, filtered, evaporated and purified by flash column chromatography on silica gel, eluting with 2% methanol in dichloromethane.

1. temperatureThe reaction mixture is refluxed for 18 hours
2. filtrationfiltered
3. customevaporated
4. custompurified by flash column chromatography on silica gel
5. washeluting with 2% methanol in dichloromethane