Isopropanol → HCID 86590383, compound

HRID 1815212Notes

Reaction equation

HRID 1815212 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[CH:19]=[C:18]([Cl:20])[N:17]=[N:16][C:15]=2Cl)=[O:13])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:22][O:23][C:24]1[CH:29]=[C:28]([CH2:30][NH2:31])[CH:27]=[CH:26][N:25]=1.C(=O)(O)[O-].[Na+].CC(O)C>O>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[CH:19]=[C:18]([Cl:20])[N:17]=[N:16][C:15]=2[NH:31][CH2:30][C:28]2[CH:27]=[CH:26][N:25]=[C:24]([O:23][CH3:22])[CH:29]=2)=[O:13])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 3776IsopropanolHCID 516892Sodium BicarbonateHCID 16227983(2-Methoxypyridin-4-yl)methanamineHCID 85890745HCID 85890745, compound

Product 1

HCID 86590383HCID 86590383, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3,6-Dichloro-pyridazine-4-carboxylic acid (4-tert-butyl-phenyl)-amide (162 mg, 0.5 mmol), C-(2-Methoxy-pyridin-4-yl)-methylamine (211 mg, 1 mmol), and sodium bicarbonate (840 mg, 20 mmol) were added to IPA (2.5 mL). The reaction was ran in microwave (150° C., 15 min). Water (5 mL) was added to the reaction and the mixture was extracted with DCM (2×5 mL). The organic layer was dried over sodium sulfate and reduced. The crude was subjected to Flash chromatography (2% MeOH/DCM) for further purification.

Workup

  1. customwas ran in microwave (150° C., 15 min)
  2. extractionthe mixture was extracted with DCM (2×5 mL)
  3. dry with materialThe organic layer was dried over sodium sulfate
  4. customThe crude was subjected to Flash chromatography (2% MeOH/DCM) for further purification

Sources & evidence

ORD record
ord-9574741268a5413db162f92ad511dcd9
Source dataset
uspto-grants-2005_04
Patent number
US06878714B2

Reaction notes

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