Methyl bromoacetate → HCID 22498599, compound

HRID 1815491Notes

Reaction equation

HRID 1815491 reaction equation
Br[CH2:2][C:3]([O:5][CH3:6])=[O:4].[NH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:15][CH2:14][CH2:13][C:12]1=[O:16].C(N(C(C)C)CC)(C)C>C(Cl)Cl>[C:3]([CH2:2][NH:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:15][CH2:14][CH2:13][C:12]1=[O:16])([O:5][CH3:6])=[O:4]

Participants

5

Reactant 3

HCID 60984Methyl bromoacetateHCID 81531DiisopropylethylamineHCID 821111-(3-Aminopropyl)-2-pyrrolidinone

Product 1

HCID 22498599HCID 22498599, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methyl bromoacetate (1.35 mL, 14.3 mmol) was added dropwise to a solution of 3-aminopropyl-2-pyrrolidinone (2.0 mL, 14.3 mmol) and diisopropylethylamine (2.7 mL) in CH2Cl2. The reaction was stirred for 12 hours and was then concentrated in vacuo, and carried forward without further purification.

Workup

  1. concentrationwas then concentrated in vacuo
  2. customcarried forward without further purification

Sources & evidence

ORD record
ord-fcb49b5a513f496eabba1bd1d9b1b35b
Source dataset
uspto-grants-2005_04
Patent number
US06878700B1

Reaction notes

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