Tributylstannane → HCID 69746630, compound

HRID 1815863Notes

Reaction equation

HRID 1815863 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](O)([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[C:17]([F:23])=[CH:16][C:15]=2[F:24])[CH:10]([CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N1CCC(OC(=O)C(C)=O)(C2C3OC=CC=3C(F)=CC=2F)C(C)C1)C1C=CC=CC=1.C([SnH](CCCC)CCCC)CCC>>[CH2:1]([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[C:17]([F:23])=[CH:16][C:15]=2[F:24])[C@H:10]([CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 5948TributylstannaneHCID 22495634HCID 22495634, compoundHCID 22495734HCID 22495734, compound

Product 1

HCID 69746630HCID 69746630, compoundYield 77%

Procedure

Beginning with 1.24 gm (3.48 mMol) 1-benzyl-3-methyl-4-hydroxy-4-(4,6-difluorobenzofur-7-yl)piperidine, 1-benzyl-3-methyl-4-(methyl oxoacetoxy)-4-(4,6-difluorobenzofur-7-yl)piperidine were prepared essentially as described in EXAMPLE 16. This material was treated with tri(n-butyl)tin hydride essentially as described in EXAMPLE 16 to prepare 0.91 gm (77%) of the desired compound.

Workup

  1. customwere prepared essentially

Sources & evidence

ORD record
ord-5975aad1dab54d90a3a4712510c852cb
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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