Pyrrolidine → HCID 22493385, compound

HRID 1816265Notes

Reaction equation

HRID 1816265 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:10].[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1.FC1C2C(=O)OC(=O)[NH:31]C=2C=CC=1>>[NH:16]1[CH2:20][CH2:19][N:31]=[C:17]1[CH2:18][NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:10]

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 27830576-Fluoroisatoic anhydrideHCID 22493346HCID 22493346, compound

Product 1

HCID 22493385HCID 22493385, compound

Procedure

{2-Amino-6-fluorophenyl}(1-pyrrolidinyl)methanone (prepared from pyrrolidine and 5-fluoro-2H-3,1-benzoxazine-2,4(1H)-dione using the methods described in Example 17) and CMI were reacted using conditions described in the general procedure for CMI coupling to give {2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]-6-fluorophenyl}(1-pyrrolidinyl)methanone.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-4ec5b4cea9bd4706b11fe586decacb1c
Source dataset
uspto-grants-2005_04
Patent number
US06884801B1

Reaction notes

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