Pyrrolidine → HCID 22493345, compound

HRID 1816266Notes

Reaction equation

HRID 1816266 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:10].[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1.ClC1C=CC2C(=O)OC(=O)[NH:29]C=2C=1>>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:10])=[C:2]([NH:1][CH2:18][C:17]2[NH:29][CH2:19][CH2:20][N:16]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 3291054-Chloroisatoic anhydrideHCID 16776289HCID 16776289, compound

Product 1

HCID 22493345HCID 22493345, compound

Procedure

(2-Amino-4-chlorophenyl)(1-pyrrolidinyl)methanone (prepared from pyrrolidine and 7-chloro-2H-3,1-benzoxazine-2,4(1H)-dione using the methods described in Example 17) and CMI were reacted using conditions described in the general procedure for CMI coupling to give (4-chloro-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]phenyl}(1-pyrrolidinyl)methanone.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-bf3e16a4f7a443f3961f9d9489970745
Source dataset
uspto-grants-2005_04
Patent number
US06884801B1

Reaction notes

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