Pyrrolidine → HCID 22493321, compound

HRID 1816304Notes

Reaction equation

HRID 1816304 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:10].[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1.BrC1C=CC2[NH:30]C(=O)OC(=O)C=2C=1>>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][CH2:18][C:17]2[NH:30][CH2:19][CH2:20][N:16]=2)=[C:3]([C:9]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:10])[CH:4]=1

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 2885615-Bromoisatoic AnhydrideHCID 22493358HCID 22493358, compound

Product 1

HCID 22493321HCID 22493321, compound

Procedure

{2-amino-5-bromophenyl}(1-pyrrolidinyl)methanone (prepared from pyrrolidine and 6-bromo-2H-3,1-benzoxazine-2,4(1H)-dione using the methods described in Example 17) and CMI were reacted using conditions described in the general procedure for CMI coupling to give {5-bromo-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]phenyl}(1-pyrrolidinyl)methanone.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-f16db3862e974e2f8f1bd1a88b88d810
Source dataset
uspto-grants-2005_04
Patent number
US06884801B1

Reaction notes

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