Pyrrolidine → HCID 22493220, compound

HRID 1816305Notes

Reaction equation

HRID 1816305 reaction equation
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[C:10]([N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:11].[NH:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1.BrC1C=C(C)C2[NH:31]C(=O)OC(=O)C=2C=1>>[Br:9][C:5]1[CH:6]=[C:7]([CH3:8])[C:2]([NH:1][CH2:19][C:18]2[NH:31][CH2:20][CH2:21][N:17]=2)=[C:3]([C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:11])[CH:4]=1

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 22493297HCID 22493297, compoundHCID 22493384HCID 22493384, compound

Product 1

HCID 22493220HCID 22493220, compound

Procedure

{2-Amino-5-bromo-3-methylphenyl}(1-pyrrolidinyl)methanone (prepared from pyrrolidine and 6-bromo-8-methyl-2H-3,1-benzoxazine-2,4-(1H)-dione using the methods described in Example 17) and CMI were reacted using conditions described in the general procedure for CMI coupling to give {5-bromo-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]-3-methylphenyl}(1-pyrrolidinyl)methanone.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-78ed05de7dea4fecb889ed520c4a38db
Source dataset
uspto-grants-2005_04
Patent number
US06884801B1

Reaction notes

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