反应详情

A solution of 8-methoxy-8-phenyl-1,4-dioxaspiro[4.5]decane (5.96 g) and 3N-hydrrochloric acid (24 ml) in tetrahydrofuran was stirred at room temperature for 24 hours. The reaction mixture was added to a mixture of sodium hydrogen carbonate solution and dimethyl ether. The organic layer was washed with sodium hydrogen carbonate solution and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (1:0-150:1 dichloromethane-methanol elution) to give 4-methoxy-4-phenylcyclohexanone (3.6 g).

1. washThe organic layer was washed with sodium hydrogen carbonate solution
2. dry with materialdried over magnesium sulfate
3. filtrationThe magnesium sulfate was filtered off
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe residue was purified by silica gel chromatography (1:0-150:1 dichloromethane-methanol elution)