反应详情

To a solution of 4-methoxy-4-phenylpiperidine-1-carboxylic acid tert-butyl ester (6.5 g) in ethyl acetate (65 ml) was added dropwise 4N-HCl/ethyl acetate (56 ml) at ambient temperature. The reaction mixture was stirred for 1.5 hours at ambient temperature. To the reaction mixture was added diisopropyl ether. The precipitate was collected by filtration to give powder. The powder was adjusted to pH 11 with 1N-NaOH, and extracted with ethyl acetate. The organic layer was separated, washed with brine, dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 4-methoxy-4-phenylpiperidine (3.47 g).

1. filtrationThe precipitate was collected by filtration
2. customto give powder
3. extractionextracted with ethyl acetate
4. customThe organic layer was separated
5. washwashed with brine
6. dry with materialdried over magnesium sulfate
7. filtrationThe magnesium sulfate was filtered off
8. customthe filtrate was evaporated under reduced pressure