Triethylamine → HCID 22494744, compound

HRID 1816748Notes

Reaction equation

HRID 1816748 reaction equation
[CH2:1]([O:4][CH:5]1[CH2:10][CH2:9][CH:8]([CH:11]2[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13][CH2:12]2)[CH2:7][CH2:6]1)[CH2:2][CH3:3].C(N(CC)CC)C.[CH3:25][S:26](Cl)(=[O:28])=[O:27]>ClCCl>[CH2:1]([O:4][CH:5]1[CH2:10][CH2:9][CH:8]([CH:11]2[CH2:16][CH2:15][CH:14]([O:17][S:26]([CH3:25])(=[O:28])=[O:27])[CH2:13][CH2:12]2)[CH2:7][CH2:6]1)[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 22494768HCID 22494768, compound

Product 1

HCID 22494744HCID 22494744, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4′-propoxybicyclohexyl-4-ol (1 g) and triethylamine (0.81 ml) in dichloromethane (10 ml) was added dropwise methanesulfonyl chloride (0.39 ml) at 0-5° C., and stirred for 3 hours. The reaction mixture was washed with water and brine, and dried, and evaporated under reduced pressure to give 4′-propoxy-4-methylsulfonyloxy-1,1′-bicyclohexane (1.44 g).

Workup

  1. washThe reaction mixture was washed with water and brine
  2. customdried
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-e06f38e7ba7f4ab298284949141a75bd
Source dataset
uspto-grants-2005_04
Patent number
US06884868B1

Reaction notes

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