Hydrochloric Acid → HCID 135540434, compound

HRID 1816942Notes

Reaction equation

HRID 1816942 reaction equation
Cl.C([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:21]3[N:22]=[C:23]([NH2:25])[N:24]=[C:20]3[N:19]=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)C1C=CC=CC=1>C(O)(=O)C>[OH:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[N:21]3[N:22]=[C:23]([NH2:25])[N:24]=[C:20]3[N:19]=[CH:18][CH:17]=2)=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11738622HCID 11738622, compound

Product 1

HCID 135540434HCID 135540434, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

Acetic acid (40 ml) and concentrated hydrochloric acid (40 ml) were added to 7-(4-benzyloxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine (the compound obtained in Reference Example 2; 5.70 g), and the obtained mixture was stirred at 80° C. for 3 hours. The resultant product was concentrated under a reduced pressure, and the residue was then washed by suspension in acetone (200 ml) and then in a 50% ethanol solution (100 ml) to obtain the captioned compound (2.60 g).

Workup

  1. customobtained in Reference Example 2
  2. concentrationThe resultant product was concentrated under a reduced pressure
  3. washthe residue was then washed by suspension in acetone (200 ml)

Sources & evidence

ORD record
ord-61b02f15595b4efbaac38a3e8c1b2478
Source dataset
uspto-grants-2009_10
Patent number
US07598244B2

Reaction notes

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