Chlorotrimethylsilane → 2-(Piperidin-4-yl)pyrimidine

A 3-neck round bottomed flask equipped with an addition funnel and condenser and containing zinc dust (2.45 g, 37.4 mmol) was flame dried. After cooling, and purging the system with nitrogen gas, 6 mL of THF was added, followed by 1,2-dibromoethane (0.298 mL, 3.46 mmol). The mixture was warmed to a vigorous reflux using a heat gun and stirred at reflux for ˜30 seconds (gas evolution was observed), then cooled to room temperature. The warming and cooling was repeated two more times. Then chlorotrimethylsilane (0.402 mL, 3.17 mmol) was added and the mixture was stirred at room temperature for 20 minutes. N-t-butoxycarbonyl-4-iodo-piperidine (known: Billotte, S. Synlett (1998), 379, 8.97 g, 28.8 mmol) in 15 mL of THF was added over a period of about 1 minutes. The reaction mixture was stirred at 50° C. for 1.5 h, then was cooled to room temperature. Meanwhile, a mixture of tri-2-furylphosphine (267 mg, 1.15 mmol) and Tris(dibenzylideneacetone)-dipalladium(0) chloroform adduct (298 mg, 0.288 mmol) was dissolved in 6 mL of THF under a nitrogen atmosphere, stirred for 15 minutes at room temperature, and added to the organozinc solution. Then a solution of 2-bromopyrimidine (5.50 g, 34.6 mmol) in a mixture of 58 mL of THF and 20 mL of N,N-dimethylacetamide was added. The reaction mixture was warmed to 80° C. and stirred for 3.5 h, then was cooled to room temperature and stirred for 36 h. The reaction mixture was filtered through celite and the filter cake was washed with ethyl acetate. The filtrate was diluted further with ethyl acetate, and washed with saturated NaHCO3 solution. The aqueous layer was back extracted with ethyl acetate, the organic layers were combined and washed twice with water and once with brine. The organic phase was dried over anhydrous MgSO4, filtered, and concentrated. Purification by flash chromatography (silica, stepwise gradient: 25% ethyl acetate/hexane, 40% ethyl acetate/hexane, 60% ethyl acetate/hexane, 80% ethyl acetate/hexane, 100% ethyl acetate) to afford 4.92 g of pure 4-(2-pyrimidyl)-piperidine product (65%). 1H NMR (500 MHz, CDCl3): δ 8.70 (d, J=5.0 Hz, 2H), 7.16 (app t, J=4.5 Hz, 1H), 4.24 (br s, 2H), 3.05 (m, 1H), 2.89 (br m, 2H), 2.01 (br d, J=13 Hz, 2H), 1.84 (dq, J=4.5, 12.5 Hz, 2H), 1.49 (s, 9H).

1. customA 3-neck round bottomed flask equipped with an addition funnel and condenser
2. temperaturewas flame
3. customdried
4. temperatureAfter cooling
5. custompurging the system with nitrogen gas, 6 mL of THF
6. additionwas added
7. temperatureThe mixture was warmed to
8. temperaturea vigorous reflux
9. temperatureat reflux for ˜30 seconds (gas evolution was observed)
10. temperatureThe warming and cooling
11. stirringthe mixture was stirred at room temperature for 20 minutes
12. stirringThe reaction mixture was stirred at 50° C. for 1.5 h
13. temperaturewas cooled to room temperature
14. stirringstirred for 15 minutes at room temperature
15. additionwas added
16. temperatureThe reaction mixture was warmed to 80° C.
17. stirringstirred for 3.5 h
18. temperaturewas cooled to room temperature
19. stirringstirred for 36 h
20. filtrationThe reaction mixture was filtered through celite
21. washthe filter cake was washed with ethyl acetate
22. additionThe filtrate was diluted further with ethyl acetate
23. washwashed with saturated NaHCO3 solution
24. extractionThe aqueous layer was back extracted with ethyl acetate
25. washwashed twice with water and once with brine
26. dry with materialThe organic phase was dried over anhydrous MgSO4
27. filtrationfiltered
28. concentrationconcentrated
29. customPurification by flash chromatography (silica, stepwise gradient

ORD record

ord-6b03a5299d084c8baeb9e48dfeb46438

Source dataset

uspto-grants-2009_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07598243B2