HCID 57880551, compound → HCID 24904374, compound

HRID 1816973Notes

Reaction equation

HRID 1816973 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:4][C:3]=1[C:21]([O:23][CH3:24])=[O:22]>Cl.O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][C:3]=1[C:21]([O:23][CH3:24])=[O:22]

Participants

4

Reactant 1

HCID 57880551HCID 57880551, compound

Product 1

HCID 24904374HCID 24904374, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 4-[4-fluoro-3-(methoxycarbonyl)phenyl]piperidine-1-carboxylate (471 mg, 1.40 mmol) was dissolved in anhydrous 4N HCl in dioxane (5mL) and stirred at r.t. for 40 min. The white solid was filtered and washed with Et2O to afford methyl 2-fluoro-5-piperidin-4-ylbenzoate.

Workup

  1. filtrationThe white solid was filtered
  2. washwashed with Et2O

Sources & evidence

ORD record
ord-6a9bd24d76764080b34f4f2f40b5d57c
Source dataset
uspto-grants-2009_10
Patent number
US07598243B2

Reaction notes

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