反应详情

tert-Butyl 4-[4-fluoro-3-(methoxycarbonyl)phenyl]piperidine-1-carboxylate (471 mg, 1.40 mmol) was dissolved in anhydrous 4N HCl in dioxane (5mL) and stirred at r.t. for 40 min. The white solid was filtered and washed with Et2O to afford methyl 2-fluoro-5-piperidin-4-ylbenzoate.

1. filtrationThe white solid was filtered
2. washwashed with Et2O