Tetrahydrofuran → HCID 23157339, compound

HRID 181716Notes

Reaction equation

HRID 181716 reaction equation
[CH2:42]([P:43]([CH2:44][CH2:45][CH2:46][CH3:47])[CH2:48][CH2:49][CH2:50][CH3:51])[CH2:52][CH2:53][CH3:54].[CH3:32][O:33][c:34]1[n:35][n:36]([CH3:41])[c:37]([CH2:39][OH:40])[cH:38]1.[F:1][c:2]1[c:3]([CH2:25][CH2:26][C:27](=[O:28])[O:29][CH2:30][CH3:31])[cH:4][cH:5][c:6]([NH:8][CH2:9][c:10]2[cH:11][c:12](-[c:16]3[c:17]([CH3:24])[cH:18][c:19]([OH:23])[cH:20][c:21]3[CH3:22])[cH:13][cH:14][cH:15]2)[cH:7]1.[N:55]([C:56]([N:57]1[CH2:58][CH2:59][CH2:60][CH2:61][CH2:62]1)=[O:63])=[N:64][C:65]([N:66]1[CH2:67][CH2:68][CH2:69][CH2:70][CH2:71]1)=[O:72].[O:73]1[CH2:74][CH2:75][CH2:76][CH2:77]1>>[F:1][c:2]1[c:3]([CH2:25][CH2:26][C:27](=[O:28])[O:29][CH2:30][CH3:31])[cH:4][cH:5][c:6]([NH:8][CH2:9][c:10]2[cH:11][c:12](-[c:16]3[c:17]([CH3:24])[cH:18][c:19]([O:23][CH2:39][c:37]4[n:36]([CH3:41])[n:35][c:34]([O:33][CH3:32])[cH:38]4)[cH:20][c:21]3[CH3:22])[cH:13][cH:14][cH:15]2)[cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 13831TributylphosphineHCID 730421,1'-(Azodicarbonyl)dipiperidineHCID 23157311HCID 23157311, compoundHCID 23157575Ethyl 3-(2-fluoro-4-{[(4'-hydroxy-2',6'-dimethylbiphenyl-3-yl)methyl]amino}phenyl)propanoate

Product 1

HCID 23157339HCID 23157339, compound

Sources & evidence

ORD record
ord-65b5ef293da3439db9528f1d044375f6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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