Chloride → [2-(4-Methoxy-benzyl)-1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl]-acetic Acid Tert-Butyl Ester

HRID 181732Notes

Reaction equation

HRID 181732 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[C:8](=[O:12])[N:7]([CH2:13][c:14]1[cH:15][cH:16][c:17]([O:20][CH3:21])[cH:18][cH:19]1)[CH2:6][CH2:5]2.[C:23]([CH3:24])([CH3:25])([CH3:26])[O:27][C:28]([CH2:29][Zn+:30])=[O:31].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[Cl-:22]>>[c:2]1([CH2:29][C:28]([O:27][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:31])[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[C:8](=[O:12])[N:7]([CH2:13][c:14]1[cH:15][cH:16][c:17]([O:20][CH3:21])[cH:18][cH:19]1)[CH2:6][CH2:5]2

Participants

5

Reactant 4

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 592164816-Bromo-2-(4-methoxy-benzyl)-3,4-dihydro-2H-isoquinolin-1-oneHCID 178451180HCID 178451180, compound

Product 1

HCID 59216409[2-(4-Methoxy-benzyl)-1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl]-acetic Acid Tert-Butyl Ester

Sources & evidence

ORD record
ord-823f9ac033e1412d8eb4ec85048e9627
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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