Water → HCID 1481889, compound

HRID 1817384Notes

Reaction equation

HRID 1817384 reaction equation
[C:1]([C:4]1[S:5][CH:6]=[CH:7][N:8]=1)(=O)[CH3:2].Cl.[NH2:10][OH:11].N1C=CC=CC=1.O>C(O)C>[S:5]1[CH:6]=[CH:7][N:8]=[C:4]1[C:1](=[N:10][OH:11])[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 5201082-Acetylthiazole

Product 1

HCID 1481889HCID 1481889, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Commercially available 2-acetyl thiazole (1.27 g) and commercially available hydroxylamine hydrochloride (830 mg) were dissolved in ethanol (40 ml) to prepare a solution. Pyridine (0.97 ml) was added to the solution, and the mixture was stirred at room temperature overnight. Water was added to the reaction solution, and the mixture was extracted three times with ethyl acetate. The organic layer was washed with water and was dried over sodium sulfate. The solvent was removed by evaporation and was dried by means of a vacuum pump to give the title compound (1.25 g, 88%).

Workup

  1. customto prepare a solution
  2. extractionthe mixture was extracted three times with ethyl acetate
  3. washThe organic layer was washed with water
  4. dry with materialwas dried over sodium sulfate
  5. customThe solvent was removed by evaporation
  6. customwas dried by means of a vacuum pump

Sources & evidence

ORD record
ord-094f45bd79ea4f52be3b87ca01a6adb1
Source dataset
uspto-grants-2009_10
Patent number
US07598258B2

Reaction notes

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