Hydrochloric Acid → HCID 178419483, compound

HRID 1817485Notes

Reaction equation

HRID 1817485 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[Br:10]Br.Cl>[OH-].[Na+]>[Br:10][C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][N:2]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 92211H-IndazoleHCID 24408Bromine

Product 1

HCID 178419483HCID 178419483, compoundYield 103.4%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

The title compound was prepared as outlined in a procedure described by B. E. Boulton, B. A. Coller, Aust. J. Chem., 1974, 27, 2343. To a mechanically stirred solution of indazole (5.0 g, 42 mmol) in 20% aq. NaOH (75 mL) was added bromine (1.4 mL, 27 mmol) dropwise. After stirring at ambient temperature for 2 h, the reaction mixture was cooled and acidified by careful addition of concentrated HCl. The solids formed were filtered and dried to give 5.5 g of the title compound.

Workup

  1. customThe title compound was prepared
  2. temperaturethe reaction mixture was cooled
  3. customThe solids formed
  4. filtrationwere filtered
  5. customdried

Sources & evidence

ORD record
ord-9dbb47513ca84367b82f7e905f90d11f
Source dataset
uspto-grants-2009_10
Patent number
US07598286B2

Reaction notes

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