Ethanol → 1-Ethoxyethanol

HRID 1817774Notes

Reaction equation

HRID 1817774 reaction equation
[CH3:1]O.[CH2:3]([OH:5])[CH3:4].[CH2:6]([OH:9])[CH2:7]C>C(O)(C)C>[CH3:3][O:5][C:6]([OH:9])([CH3:7])[CH3:1].[CH2:3]([O:5][CH:6]([OH:9])[CH3:7])[CH3:4]

Participants

6

Reactant 3

HCID 702EthanolHCID 887MethanolHCID 10311-Propanol

Product 2

HCID 101298981-EthoxyethanolHCID 108878272-Propanol, 2-methoxy-

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

The 4,5-diacyl-[1,4,5]-oxadiazepines obtained in this reaction step can be obtained especially by precipitation from alcohols such as methanol, ethanol, propanol, isopropanol, methoxyisopropanol and ethoxyethanol. They are generally obtained in yields of from 40 to 76% and in a purity of more than 95%. It is not necessary, however, to isolate those intermediates; they can be introduced directly into the next step by replacing the solvent of reaction step (1) by the solvent of reaction step (2).

Sources & evidence

ORD record
ord-225c05a72f1e498a821f8c46e62abc5c
Source dataset
uspto-grants-2009_10
Patent number
US07598376B2

Reaction notes

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