Phosphorus oxychloride → 2-chloro-2,5a,6,7,8,9,9a,10-octahydro-1H-benzo[g]quinolin-5-one

HRID 1817811Notes

Reaction equation

HRID 1817811 reaction equation
[NH:1]1[C:10]2[CH2:9][CH:8]3[CH2:11][CH2:12][CH2:13][CH2:14][CH:7]3[C:6](=[O:15])[C:5]=2[CH:4]=[CH:3][C:2]1=O.P(Cl)(Cl)([Cl:19])=O>>[Cl:19][CH:2]1[CH:3]=[CH:4][C:5]2[C:6](=[O:15])[CH:7]3[CH2:14][CH2:13][CH2:12][CH2:11][CH:8]3[CH2:9][C:10]=2[NH:1]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 578832706,7,8,9,9a,10-hexahydrobenzo[g]quinoline-2,5(1H,5aH)-dione

Product 1

HCID 690381592-chloro-2,5a,6,7,8,9,9a,10-octahydro-1H-benzo[g]quinolin-5-one

Procedure

In close analogy to (Shanazarov, A. K.; Kuzovkin, V. A.; Chistjakov, V. V.; Granik, V. G. Khim. Geterotsikl. Soedin. 1991, (1) 86-92) 6,7,8,9,9a,10-hexahydro-1H,5aH-benzo[g]quinoline-2,5-dione was treated with phosphoryl chloride (POCl3) to give after chromatographical separation the title compound as a colorless solid.

Workup

  1. customto give
  2. customafter chromatographical separation the title compound as a colorless solid

Sources & evidence

ORD record
ord-a6763bb8d10b4c90a36717cb346ea407
Source dataset
uspto-grants-2009_10
Patent number
US07598384B2

Reaction notes

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