2-Chloro-7,7-dimethyl-7,8-dihydroquinolin-5(6H)-one → 2-Isobutoxy-7,7-dimethyl-7,8-dihydro-6H-quinolin-5-one hydrochloride

HRID 1817818Notes

Reaction equation

HRID 1817818 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:8](=[O:12])[CH2:7][C:6]([CH3:14])([CH3:13])[CH2:5][C:4]=2[N:3]=1>C(O)C(C)C>[ClH:1].[CH2:8]([O:12][C:2]1[CH:11]=[CH:10][C:9]2[C:8](=[O:12])[CH2:7][C:6]([CH3:14])([CH3:13])[CH2:5][C:4]=2[N:3]=1)[CH:9]([CH3:10])[CH3:4]

Participants

3

Reactant 1

HCID 148125452-Chloro-7,7-dimethyl-7,8-dihydroquinolin-5(6H)-one

Product 1

HCID 690385882-Isobutoxy-7,7-dimethyl-7,8-dihydro-6H-quinolin-5-one hydrochlorideYield 35%

Reagents, catalysts & solvents 1

HCID 6560IsobutanolSolvent

Procedure

In analogy to the procedure described in Example 9, 2-chloro-7,7-dimethyl-7,8-dihydro-6H-quinolin-5-one was treated with iso-butyl alcohol to give the title compound in 35% yield.

Sources & evidence

ORD record
ord-31f381eb02a646eaaefb6d89be1b36f9
Source dataset
uspto-grants-2009_10
Patent number
US07598384B2

Reaction notes

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