Hydrochloric Acid → HCID 68871362, compound

HRID 1817852Notes

Reaction equation

HRID 1817852 reaction equation
NC1C=C(S(CC)(=O)=O)C=CC=1NCC1CC1.[CH:18]1([CH2:21][N:22]2[C:26]3[CH:27]=[CH:28][C:29]([S:31]([CH2:34][CH3:35])(=[O:33])=[O:32])=[CH:30][C:25]=3[N:24]=[C:23]2[CH2:36][C:37]([CH3:40])([CH3:39])[CH3:38])[CH2:20][CH2:19]1.[ClH:41]>C(OCC)(=O)C>[ClH:41].[CH:18]1([CH2:21][N:22]2[C:26]3[CH:27]=[CH:28][C:29]([S:31]([CH2:34][CH3:35])(=[O:32])=[O:33])=[CH:30][C:25]=3[N:24]=[C:23]2[CH2:36][C:37]([CH3:38])([CH3:40])[CH3:39])[CH2:19][CH2:20]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 115808221-(Cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-(ethylsulfonyl)-1H-benzimidazoleHCID 68869386HCID 68869386, compound

Product 1

HCID 68871362HCID 68871362, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

The title compound was prepared according to the procedure described in Step F of Example 1 using 2-amino-1-(N-cyclopropylmethylamino)-4-(ethylsulfonyl)benzene (Step E) instead of 2-amino-1-(N-cyclopropylmethylamino)-4-(isopropylsulfonyl)benzene. Obtained 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-(ethylsulfonyl)-1H-benzimidazole was dissolved in ethyl acetate and to the solution was added 4 N hydrogen chloride in ethyl acetate. The precipitate was collected by filtration to afford the title compound as a white solid.

Workup

  1. customThe title compound was prepared
  2. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-8f0c4607e5004c84849e867adf6a5cf6
Source dataset
uspto-grants-2009_10
Patent number
US07598393B2

Reaction notes

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