1-Chloro-4-(isopropylsulfonyl)-2-nitrobenzene → 4-({[4-(Isopropylsulfonyl)-2-nitrophenyl]amino}methyl)tetrahydro-2H-pyran-4-ol

HRID 1817868Notes

Reaction equation

HRID 1817868 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH:11]([CH3:13])[CH3:12])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:14]([O-:16])=[O:15].Cl.[NH2:18][CH2:19][C:20]1([OH:26])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>C(N(CC)CC)C>[CH:11]([S:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:18][CH2:19][C:20]2([OH:26])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)=[C:3]([N+:14]([O-:16])=[O:15])[CH:4]=1)(=[O:10])=[O:9])([CH3:13])[CH3:12]

Participants

4

Reactant 2

HCID 235592021-Chloro-4-(isopropylsulfonyl)-2-nitrobenzeneHCID 573458144-(Aminomethyl)oxan-4-ol--hydrogen chloride (1/1)

Product 1

HCID 688707234-({[4-(Isopropylsulfonyl)-2-nitrophenyl]amino}methyl)tetrahydro-2H-pyran-4-ol

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound was prepared according to the procedure described in Step A of Example 5 from 1-chloro-4-(isopropylsulfonyl)-2-nitrobenzene (Step C of Example 1), 4-(aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride (Step A of Example 19) and triethylamine.

Sources & evidence

ORD record
ord-094f52bf22d54b69a84cf71130ba3843
Source dataset
uspto-grants-2009_10
Patent number
US07598393B2

Reaction notes

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