4-(Aminomethyl)oxan-4-ol--hydrogen chloride (1/1) → 5-(Isopropylsulfonyl)-3-nitro-N-(tetrahydro-2H-pyran-4-ylmethyl)pyridin-2-amine

HRID 1817874Notes

Reaction equation

HRID 1817874 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([S:11]([CH:14]([CH3:16])[CH3:15])(=[O:13])=[O:12])=[CH:4][N:3]=1.Cl.[NH2:18][CH2:19][C:20]1(O)[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>C(N(CC)CC)C>[CH:14]([S:11]([C:5]1[CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]([NH:18][CH2:19][CH:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)=[N:3][CH:4]=1)(=[O:13])=[O:12])([CH3:16])[CH3:15]

Participants

4

Reactant 2

HCID 573458144-(Aminomethyl)oxan-4-ol--hydrogen chloride (1/1)HCID 862419792-Chloro-5-(isopropylsulfonyl)-3-nitropyridine

Product 1

HCID 688713665-(Isopropylsulfonyl)-3-nitro-N-(tetrahydro-2H-pyran-4-ylmethyl)pyridin-2-amine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound was prepared according to the procedure described in Step A of Example 5 from 2-chloro-5-(isopropylsulfonyl)-3-nitropyridine (Step D), 4-(aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride (Step A of Example 19) and triethylamine.

Sources & evidence

ORD record
ord-e4ea087fbbff4120901151a99e64fee1
Source dataset
uspto-grants-2009_10
Patent number
US07598393B2

Reaction notes

Loading…