Diisopropylethylamine → 4-Bromo-2-nitro-N-[2-(trifluoromethoxy)ethyl]aniline

HRID 1817898Notes

Reaction equation

HRID 1817898 reaction equation
Cl.[F:2][C:3]([F:9])([F:8])[O:4][CH2:5][CH2:6][NH2:7].[Br:10][C:11]1[CH:16]=[CH:15][C:14](F)=[C:13]([N+:18]([O-:20])=[O:19])[CH:12]=1.C(N(CC)C(C)C)(C)C>>[Br:10][C:11]1[CH:16]=[CH:15][C:14]([NH:7][CH2:6][CH2:5][O:4][C:3]([F:9])([F:8])[F:2])=[C:13]([N+:18]([O-:20])=[O:19])[CH:12]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 27363284-Bromo-1-fluoro-2-nitrobenzeneHCID 448908072-(Trifluoromethoxy)ethan-1-amine hydrochloride

Product 1

HCID 688735474-Bromo-2-nitro-N-[2-(trifluoromethoxy)ethyl]aniline

Procedure

The title compound was prepared according to the procedure described in Step A of Example 5 from 2-(trifluoromethoxy)ethanamine hydrochloride (J. Org. Chem. 2001, 66, 1061-1063), 4-bromo-1-fluoro-2-nitrobenzene (Wako Pure Chemical Industries, Ltd.) and N,N-diisopropylethylamine.

Sources & evidence

ORD record
ord-31d950ee22ec4e3dafaf373ea9ded853
Source dataset
uspto-grants-2009_10
Patent number
US07598393B2

Reaction notes

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