Diisopropylethylamine → 4-(Ethylsulfonyl)-2-nitro-N-(tetrahydro-2H-pyran-2-ylmethyl)aniline

HRID 1817917Notes

Reaction equation

Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH3:12])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:13]([O-:15])=[O:14].[NH2:16][CH2:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][O:19]1.C(N(CC)C(C)C)(C)C>>[CH2:11]([S:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:16][CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][O:19]2)=[C:3]([N+:13]([O-:15])=[O:14])[CH:4]=1)(=[O:10])=[O:9])[CH3:12]

Participants

Reactant 3

HCID 81531Diisopropylethylamine

HCID 97924(Tetrahydro-2H-pyran-2-ylmethyl)amine

HCID 15158591-Chloro-4-(ethylsulfonyl)-2-nitrobenzene

Product 1

HCID 688709904-(Ethylsulfonyl)-2-nitro-N-(tetrahydro-2H-pyran-2-ylmethyl)aniline

Procedure

The title compound was prepared according to the procedure described in Step A of Example 5 from 1-chloro-4-(ethylsulfonyl)-2-nitrobenzene (step C of Example 2), 2-aminomethyltetrahydropyran (Sciences Chimiques 1972, 3, 685-688) and N,N-diisopropylethylamine.

Sources & evidence

ORD record: ord-b3c237a170e84b028c39850f3825a33a
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07598393B2

Reaction notes

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