Hydrochloric Acid → HCID 10236614, compound

HRID 1818063Notes

Reaction equation

HRID 1818063 reaction equation
C([NH:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][C:9]([S:15]([NH:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)(=[O:17])=[O:16])=[CH:10]2)(=O)C.C(O)CC.Cl>O>[NH2:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][C:9]([S:15]([NH:18][CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)(=[O:17])=[O:16])=[CH:10]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10311-PropanolHCID 10215509HCID 10215509, compound

Product 1

HCID 10236614HCID 10236614, compoundYield 74.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5-Acetylamino-N-benzylnaphthalene-2-sulfonamide (compound No. 5-1; 175 mg, 0.494 mmol) was suspended to a mixed solvent of 1-propanol (3.0 ml) and water (1.5 ml). Concentrated hydrochloric acid (1.5 ml) was added to the suspension and the mixture was refluxed for 1 hour. After cooling to room temperature, the separated crystal was collected and washed with 1-propanol and isopropyl ether to give the title compound as a light yellow crystal (128 mg, 74.4%).

Workup

  1. temperaturethe mixture was refluxed for 1 hour
  2. customthe separated crystal was collected
  3. washwashed with 1-propanol and isopropyl ether

Sources & evidence

ORD record
ord-d0ae41470756438b801e0974e036751d
Source dataset
uspto-grants-2009_10
Patent number
US07598418B2

Reaction notes

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