Water → HCID 10193659, compound

HRID 1818064Notes

Reaction equation

HRID 1818064 reaction equation
[C:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11]([S:15](Cl)(=[O:17])=[O:16])=[CH:10][CH:9]=[CH:8]2)(=[O:3])[CH3:2].[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(N(CC)CC)C.[OH2:34]>O1CCCC1>[C:25]([O:3][CH2:1][CH3:2])(=[O:34])[CH3:20].[CH:5]([O:34][CH:20]([CH3:21])[CH3:19])([CH3:6])[CH3:14].[C:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11]([S:15]([NH:26][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)(=[O:17])=[O:16])=[CH:10][CH:9]=[CH:8]2)(=[O:3])[CH3:2]

Participants

7

Reactant 4

HCID 962WaterHCID 7504BenzylamineHCID 8471TriethylamineHCID 18948941HCID 18948941, compound

Product 2

HCID 10193659HCID 10193659, compoundYield 81.1%HCID 22281796Diisopropylether ethyl acetate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

6-(Acetylamino)naphthalene-1-sulfonyl chloride (280 mg, 0.987 mmol) was added to a solution of benzylamine (127 mg, 1.19 mmol) and triethylamine (0.17 ml, 1.22 mmol) in tetrahydrofuran (3.0 ml), and the mixture was stirred at room temperature for 1 hour. Water (10 ml) was added to the reaction solution, and after the mixture was stirred for 10 minutes, the resulting solid was collected. The solid was washed with water and a mixed solvent of ethyl acetate/isopropyl ether (1/1) to give the title compound as a white solid (284 mg, 81.1%).

Workup

  1. stirringafter the mixture was stirred for 10 minutes
  2. customthe resulting solid was collected
  3. washThe solid was washed with water

Sources & evidence

ORD record
ord-1b45e07e80f24c64bd300a3ab89abd45
Source dataset
uspto-grants-2009_10
Patent number
US07598418B2

Reaction notes

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