反应详情

温度

50 °C

2′-deoxyuridine (4.00 g, 17.5 mmol) and triphenylmethyl chloride (5.37 g, 19.25 mmol) were stirred in anhydrous pyridine (70 ml) at 50° C. overnight. Additional triphenylmethyl chloride (1.00 g, 3.59 mmol) was added after 18 hours, and the mixture was stirred for a further 4 hours at 50° C. The reaction mixture was then poured into ice-H2O (300 ml) and stirred vigorously. The precipitate was extracted with EtOAc (3×100 ml). The organic solution was then washed with 0.5 M HCl (4×100 ml), dried with MgSO4 and filtered. The filtrate was then washed further with EtOAc, which was then evaporated, and finally with DCM. Solvent was removed using a Buchi rotary evaporator, and finally with the vacuum pump.

1. stirringstirred vigorously
2. extractionThe precipitate was extracted with EtOAc (3×100 ml)
3. washThe organic solution was then washed with 0.5 M HCl (4×100 ml)
4. dry with materialdried with MgSO4
5. filtrationfiltered
6. washThe filtrate was then washed further with EtOAc, which
7. customwas then evaporated
8. customSolvent was removed
9. customa Buchi rotary evaporator