Hydrochloric Acid → HCID 68709452, compound

HRID 1818817Notes

Reaction equation

HRID 1818817 reaction equation
[C:1]([NH:5][CH2:6][C:7](=[O:27])[CH2:8][CH2:9][N:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[S:11]1(=[O:26])=[O:25])([CH3:4])([CH3:3])[CH3:2].C(OC(=O)N)(C)(C)C.CO.[ClH:38]>C(OCC)C.O1CCOCC1>[ClH:38].[C:1]([NH:5][CH2:6][C:7](=[O:27])[CH2:8][CH2:9][N:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[S:11]1(=[O:26])=[O:25])([CH3:4])([CH3:2])[CH3:3]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 68713725HCID 68713725, compound

Product 1

HCID 68709452HCID 68709452, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

The clear oil, 1-(tert-butylamino)-4-(2,2-dioxido-3-phenyl-2,1,3-benzothiadiazol-1(3H)-yl)butan-2-one-carbamic acid tert-butyl ester, was dissolved in diethyl ether and methanol and 4N HCl in dioxane was added a precipitate formed. The reaction was filtered to afford 12 mg of 1-(tert-butylamino)-4-(2,2-dioxido-3-phenyl-2,1,3-benzothiadiazol-1(3H)-yl)butan-2-one hydrochloride as a white solid.

Workup

  1. customformed
  2. filtrationThe reaction was filtered

Sources & evidence

ORD record
ord-7b3a132ce0eb4c5d9108d0f003149a40
Source dataset
uspto-grants-2009_10
Patent number
US07601722B2

Reaction notes

Loading…