反应详情

236 mg (1.16 mmol) 8-methyl-2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine-6-carbonitrile, 234 mg (1.75 mmol) bicyclopropyl-1-ylamine hydrochloride and 177 mg (1.75 mmol) triethylamine in 25 ml THF are heated 4 h at reflux. The mixture is cooled down and evaporated. The residue is dissolved in ethyl acetate and extracted with water. After purification on a short path of silicagel, 63 mg of the title compound are isolated as yellow crystals. F: 171-172° C.

1. temperatureat reflux
2. temperatureThe mixture is cooled down
3. customevaporated
4. dissolutionThe residue is dissolved in ethyl acetate
5. extractionextracted with water
6. customAfter purification on a short path of silicagel, 63 mg of the title compound
7. customare isolated as yellow crystals
8. custom171-172° C.