HCID 18452906, compound → 2-Mercaptobenzonitrile

HRID 1819286Notes

Reaction equation

HRID 1819286 reaction equation
[S:1](O)(=O)(=O)[CH3:2].[CH2:6]1[CH:15]2C([CH2:11][CH2:12][CH2:13][CH2:14]2)CC[NH:7]1>CC(C)=O.C(=O)([O-])[O-].[K+].[K+]>[SH:1][C:2]1[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=1[C:6]#[N:7]

Participants

4

Reactant 1

HCID 18452906HCID 18452906, compound

Product 1

HCID 110189262-Mercaptobenzonitrile

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 11430Potassium CarbonateSolvent

Procedure

Following the procedures for Example 22, Step C, decahydroisoquinoline mesylate from preparation 3 (102 mg, 0.28 mmol) in acetone (0.5 mL), potassium carbonate solid (38 mg, 0.28 mmol, twice) and 2-mercaptobenzonitrile (38 mg, 0.286 mmol, twice) gave, after flash chromatography (hexanes-ethyl acetate 2:1), the desired product as an oil (64 mg) in 57% yield.

Sources & evidence

ORD record
ord-d17ec1bf9a594fe49a0597fe2c5558df
Source dataset
uspto-grants-2009_10
Patent number
US07601738B2

Reaction notes

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