HCID 68828336, compound → HCID 68828392, compound

HRID 1819356Notes

Reaction equation

HRID 1819356 reaction equation
C([O:8][C:9]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:10]=1[CH:17]1[CH2:21][N:20]([C:22]2[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=2)[C:25]([NH2:27])=[O:26])[C:19](=[O:31])[CH2:18]1)C1C=CC=CC=1>CCO.CCOC(C)=O.[Pd]>[OH:8][C:9]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:10]=1[CH:17]1[CH2:21][N:20]([C:22]2[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=2)[C:25]([NH2:27])=[O:26])[C:19](=[O:31])[CH2:18]1

Participants

5

Reactant 1

HCID 68828336HCID 68828336, compound

Product 1

HCID 68828392HCID 68828392, compoundYield 85.1%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

3-[4-(2-Benzyloxy-4-methoxyphenyl)-2-oxo-pyrrolidin-1-yl]benzamide (1.8 g, crude) was dissolved in 50 mL of EtOH and 20 mL of EtOAc. 10% Pd/C (200 mg) was added and the mixture was stirred under H2 for 20 h. After filtration and concentration, the residue was purified on silica gel to give 1.2 g of the desired product.

Workup

  1. filtrationAfter filtration and concentration
  2. customthe residue was purified on silica gel

Sources & evidence

ORD record
ord-52043c408697406984c36413a3518054
Source dataset
uspto-grants-2009_10
Patent number
US07601742B2

Reaction notes

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