反应详情

Nitronium tetrafluoroborate (14.0 g, 105 mmol) was added to a solution of 2-trifluoromethoxy-benzaldehyde (10.0 g, 52.6 mmol) in nitromethane (30 mL) at room temperature. The mixture was stirred for 2 h and was then quenched with ice water and extracted with ether (100 mL). The organic layer was separated, washed with water, dried over MgSO4 and chromatographed with 5% EtOAc/hexanes to afford 7.52 g of 5-nitro-2-trifluoromethoxy-benzaldehyde (60.8%) as a pale yellow solid.

1. customwas then quenched with ice water
2. extractionextracted with ether (100 mL)
3. customThe organic layer was separated
4. washwashed with water
5. dry with materialdried over MgSO4
6. customchromatographed with 5% EtOAc/hexanes