反应详情

温度

140 °C

To a suspension of 3-perylenoyl propanoic acid methyl ester (360.2 mg, 0.983 mmol) in 2.0 mL diethylene glycol, 98% hydrazine hydrate (150.6 μL, 2.949 mmol) and powdered potassium hydroxide (275.3 mg, 4.916 mmol) were added. The reaction mixture was heated to 140° C. for 2 hrs, then to 190° C. and kept over night, cooled to room temperature, diluted with 20 mL water, acidified with 0.5 mL concentrated hydrochloric acid, the precipitate formed was filtered, washed with water to pH 7.0, dried on air or washed with acetone, then with a mixture chloroform-methanol (8:2 by vol.). The filtrate was concentrated in vacuo. The crude product was applied onto a silica gel column and eluted with chloroform to 20% methanol in chloroform to give perylenebutanoic acid (228.9 mg, 68.8%). Rf 0.66 (system 3). 1H-NMR (CDCl3/DMSO-d6, 20:1) (δ, ppm): 1.92 (quin., 2H, 3-CH2), 2.38 (t, 2H, J 7.00 Hz, 2-CH2), 3.03 (t, 2H, J 7.00 Hz, 4-CH2), 7.41 (d, 1H, J 7.82 Hz, Ar), 7.43-7.64 (m, 3H, Ar), 7.76 (d, 1H, J 3.42 Hz, Ar), 7.80 (d, 1H, J 3.41 Hz, Ar), 8.00 (d, 1H, J 8.49 Hz, Ar), 8.21-8.60 (m, 4H, Ar).

1. additionwere added
2. waitto 190° C. and kept over night
3. temperaturecooled to room temperature
4. customthe precipitate formed
5. filtrationwas filtered
6. washwashed with water to pH 7.0
7. customdried on air
8. washwashed with acetone
9. concentrationThe filtrate was concentrated in vacuo
10. washeluted with chloroform to 20% methanol in chloroform