Triethylamine → HCID 24899448, compound

HRID 1819859Notes

Reaction equation

HRID 1819859 reaction equation
[CH2:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[CH2:4][CH2:3][CH:2]1[NH2:14].[C:15]1([CH3:24])[C:16]([C:21](Cl)=[O:22])=[CH:17][CH:18]=[CH:19][CH:20]=1.C(N(CC)CC)C>O1CCCC1>[CH3:24][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[C:21]([NH:14][C:2]1[CH:3]=[CH:4][C:5]2[O:6][C:7]3[CH2:13][CH2:12][CH2:11][CH2:10][C:8]=3[C:9]=2[CH:1]=1)=[O:22]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 702762-Methylbenzoyl chlorideHCID 21221605HCID 21221605, compound

Product 1

HCID 24899448HCID 24899448, compoundYield 65.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the procedure of Example 1, tetrahydro-dibenzofuran-2-ylamine (0.94 g, 5.0 mmol), o-toluoyl chloride (0.69 mL, 5.2 mmol), and triethylamine (2.1 mL, 15 mmol) in tetrahydrofuran (30 mL) provided 2-methyl-N-(6,7,8,9-tetrahydro-dibenzofuran-2-yl)-benzamide (1.0 g). Mp 209-210° C.;Anal. Calcd. for C20H19NO2: C, 78.66; H, 6.27; N, 4.59; Found: C, 78.52; H, 6.28; N, 4.67.

Sources & evidence

ORD record
ord-2c561fcb800445909a62bc73efae7c48
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

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