Isonicotinoyl chloride hydrochloride → HCID 24897852, compound

HRID 1819913Notes

Reaction equation

HRID 1819913 reaction equation
[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH2:16].Cl.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1>ClC(Cl)C>[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH:16][C:18](=[O:25])[C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 12262826Isonicotinoyl chloride hydrochlorideHCID 57890287HCID 57890287, compound

Product 1

HCID 24897852HCID 24897852, compoundYield 44.1%

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

Following the procedure of Example 1, 6,7,8,9,10,11-Hexahydro-benzo[b]-cycloocta[d]furan-2-ylamine (0.20 g, 0.92 mmol), isonicotinoyl chloride hydrochloride (0.20 g, 1.1 mmol), and poly(vinylpyridine) (0.5 g) in dichloroethane (12 mL) provided N-(6,7,8,9,10,11-hexahydrobenzo[b]cycloocta[d]furan-2-yl)isonicotinamide (0.13 g). MS (ESI) m/z 321 ([M+H]+); MS (ESI) m/z 319 ([M−H]−).

Sources & evidence

ORD record
ord-ec8eb8b3ebc94879984a1b2a8c48ea7f
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

Loading…