Hexane → HCID 57888639, compound

Temperature

-78 °C

A solution of 1-Bromo-4-fluorobenzene (5.32 mL, 48.4 mmol) in THF (100 mL) was cooled to −78° C., and treated with the dropwise addition of 1.6 M BuLi in hexane (30.2 mL, 48.4 mmol), at a rate which did not allow the temperature of the reaction to exceed −60° C. The mixture was stirred at −78° C. for 30 minutes, then treated with the dropwise addition of a solution of tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate (5 g, 22.00 mmol) in THF (50 mL) at a rate which did not allow the temperature to exceed −60° C. The mixture was stirred at −78° C. for 1.5H, then allowed to warm to 10° C. and quenched with saturated NH4Cl (50 mL). The layers were separated, and the organic phase was concentrated in-vacuo. The aqueous was extracted with ethyl acetate (100 mL), and the organic phase was combined with the residue from the original organic phase. This solution was washed 3× with water, 1× with brine, dried over sodium sulfate, and concentrated in-vacuo. The residue was digested with hexanes (70 mL), and the resulting white powder was collected by filtration, rinsed with hot hexanes, and dried under vacuum to yield the title compound (3.3 g, 10.20 mmol, 46.4% yield). MS (ESI+)=324.4, (M+H)+, 250.3, (M-tBuOH)+.

1. customthe temperature of the reaction
2. customto exceed −60° C
3. customto exceed −60° C
4. stirringThe mixture was stirred at −78° C. for 1.5H
5. temperatureto warm to 10° C.
6. customquenched with saturated NH4Cl (50 mL)
7. customThe layers were separated
8. concentrationthe organic phase was concentrated in-vacuo
9. extractionThe aqueous was extracted with ethyl acetate (100 mL)
10. washThis solution was washed 3× with water, 1× with brine
11. dry with materialdried over sodium sulfate
12. concentrationconcentrated in-vacuo
13. filtrationthe resulting white powder was collected by filtration
14. washrinsed with hot hexanes
15. customdried under vacuum

ORD record

ord-3e740dcd31bb412eb0eb7aebd6d633d8

Source dataset

uspto-grants-2009_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07601844B2