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HRID1820711

反应详情

EQUATION

反应方程式

HRID 1820711 的结构方程式

REACTANTS

反应物

4
结构：c1ccc(P(c2ccccc2)c2ccccc2)cc1
HCID11776

Triphenylphosphine

C18H15P

结构：OC(CF)CF
HCID67985

1,3-Difluoro-2-propanol

C3H6F2O

结构：CC(C)OC(=O)/N=N/C(=O)OC(C)C
HCID5363146

Diisopropyl azodicarboxylate

C8H14N2O4

结构：O=C(c1cc([N+](=O)[O-])ccc1O)N1CCN(c2ccc(C(F)(F)F)cc2)CC1
HCID69036826

未命名化合物

PRODUCTS

生成物

1
结构：O=C(c1cc([N+](=O)[O-])ccc1OC(CF)CF)N1CCN(c2ccc(C(F)(F)F)cc2)CC1
HCID69038209

未命名化合物

收率 113.6%

PROCEDURE

实验过程

A solution of (2-hydroxy-5-nitro-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone (50 mg), 1,3-difluoro-2-propanol [453-13-4] (27 mg), triphenylphosphine (76 mg) and diisopropylazodicarboxylate (48 mg) was refluxed overnight, concentrated in vacuo and purified by column chromatography (SiO2) to yield the title compound as a colorless solid (68 mg). MS (m/e): 474.1 (M+H+, 100%).

WORKUP

后处理

  1. concentrationconcentrated in vacuo
  2. custompurified by column chromatography (SiO2)