反应详情

To 2-tert-Butoxy-5-methanesulfonyl-benzoic acid methyl ester (1.58 g) in THF (25 mL) was added a solution lithium hydroxide monohydrate (0.35 g) in water (25 mL), and the reaction mixture was stirred at room temperature for 4 hours. After such time, the THF was removed in vacuo and to the remaining aqueous solution was added 8 mL of 1N HCl solution, leading to precipitation of the compound. The precipitate was filtered off and washed several times with water to yield the title compound (1.00 g) as a white solid. MS (m/e): 289.9 (M+NH4+).

1. customAfter such time, the THF was removed in vacuo and to the remaining aqueous solution
2. additionwas added 8 mL of 1N HCl solution
3. customleading to precipitation of the compound
4. filtrationThe precipitate was filtered off
5. washwashed several times with water