Trifluoroacetic acid → 2-Methoxy-6-(piperazin-1-yl)pyrazine

HRID 1820758Notes

Reaction equation

HRID 1820758 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[N:18][CH:17]=[C:16]([O:20][CH3:21])[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[CH3:21][O:20][C:16]1[N:15]=[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:19]=[N:18][CH:17]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 690413416'-Methoxy-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester

Product 1

HCID 133186982-Methoxy-6-(piperazin-1-yl)pyrazine

Procedure

Prepared in analogy to example 4.10(c) from 6′-Methoxy-2,3,5,6-tetrahydro-[1,2′]bipyrazinyl-4-carboxylic acid tert-butyl ester and trifluoroacetic acid. MS (m/e): 195.1 (MH+, 80%)

Sources & evidence

ORD record
ord-6200a4eaf50c48b5a8c666f95d43d726
Source dataset
uspto-grants-2009_10
Patent number
US07605163B2

Reaction notes

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