反应详情

To 28.3 mmol 3,4-difluoro-benzenesulfinic acid and 36.8 mmol triethylamine in 100 ml DMF was added 70.7 mmol 1-chloro-3-iodopropane and the mixture stirred at RT for 1 h. The reaction mixture was then poured onto water and extracted three times with ethyl acetate. The combined organic phases were then washed with saturated aq. NaCl solution, dried over Na2SO4, and concentrated in vacuo. The residue was chromatographed on silica gel (eluant: ethyl acetate/heptane gradient) to afford the title compound.

1. additionThe reaction mixture was then poured onto water
2. extractionextracted three times with ethyl acetate
3. washThe combined organic phases were then washed with saturated aq. NaCl solution
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo
6. customThe residue was chromatographed on silica gel (eluant: ethyl acetate/heptane gradient)